Journal article
Meta-Analysis of Copper and Iron in Parkinson's Disease Brain and Biofluids
S Genoud, AM Senior, DJ Hare, KL Double
Movement Disorders | WILEY | Published : 2020
DOI: 10.1002/mds.27947
Abstract
Background: Variations in study quality and design complicate interpretation of the clinical significance of consistently reported changes in copper and iron levels in human Parkinson's disease brain and biofluids. Methods: We systematically searched literature databases for quantitative reports of biometal levels in the degenerating substantia nigra (SN), CSF, serum, and plasma in Parkinson's disease compared with healthy age-matched controls and assessed the quality of these publications. The primary outcomes of our analysis confirmed SN copper and iron levels are decreased and increased, respectively, in the Parkinson's disease brain. We applied a novel Quality Assessment Scale for Human ..
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Awarded by Institute of Neurosciences, Mental Health and Addiction
Funding Acknowledgements
This study was funded by Parkinson's New South Wales, Parkinson's Victoria, the Australian Research Council (DE180101520 to Dr. Senior) and the National Health and Medical Research Council (GNT1122981 to Assoc. Prof. Hare). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.