Journal article

The dynamics of oligodendrocyte generation: how distinct is the mouse from the human?

David G Gonsalvez, Georgina A Craig, Darragh M Walsh, Barry D Hughes, Rhiannon J Wood, Sang Won Yoo, Simon S Murray, Junhua Xiao

Cold Spring Harbor Laboratory

Abstract

Murine oligodendrocyte generation dynamics are considered distinct from those in the human, with implications for cross-species differences in neural homeostasis, injury response and ability to functionally adapt circuits through myelin plasticity. We identify that murine oligodendrocyte precursors do not vary their cell division times in vivo and determine how daily production rates change over a lifespan. We show that murine oligodendrogenesis closely resembles what is reported for the human.