Journal article

Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes

Crystal Man Ying Lee, Stephen Colagiuri, Mark Woodward, Edward W Gregg, Robert Adams, Fereidoun Azizi, Rafael Gabriel, Tiffany K Gill, Clicerio Gonzalez, Allison Hodge, David R Jacobs, Joshua J Joseph, Davood Khalili, Dianna J Magliano, Kirsten Mehlig, Roger Milne, Gita Mishra, Morgana Mongraw-Chaffin, Julie A Pasco, Masaru Sakurai Show all

BMJ Open Diabetes Research & Care | BMJ PUBLISHING GROUP | Published : 2019

Abstract

Objective: There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful. Research design and methods: We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services


Awarded by NIH/NIDDK


Awarded by National Heart, Lung, and Blood Institute (NHLBI)


Awarded by Jackson State University from the National Heart, Lung, and Blood Institute (NHLBI)


Awarded by Tougaloo College from the National Heart, Lung, and Blood Institute (NHLBI)


Awarded by Mississippi State Department of Health from the National Heart, Lung, and Blood Institute (NHLBI)


Awarded by University of Mississippi Medical Center from the National Heart, Lung, and Blood Institute (NHLBI)


Awarded by Australian National Health and Medical Research Council


Awarded by National Heart, Lung, and Blood Institute


Awarded by NCRR


Awarded by Swedish government


Awarded by Swedish county councils, the ALF


Awarded by Instituto de Salud Carlos III, Spain


Awarded by Jackson State University from the National Institute for Minority Health and Health Disparities (NIMHD)


Awarded by Tougaloo College from the National Institute for Minority Health and Health Disparities (NIMHD)


Awarded by Mississippi State Department of Health from the National Institute for Minority Health and Health Disparities (NIMHD)


Awarded by University of Mississippi Medical Center from the National Institute for Minority Health and Health Disparities (NIMHD)


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (grant number 1103242). The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under contract nos. HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I. ES was supported by NIH/NIDDK grant K24DK106414. The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN2682018000031, HHSN2682018000041, HHSN2682018000051, HHSN2682018000061 and HHSN2682018000071 from the National Heart, Lung, and Blood Institute (NHLBI). The Jackson Heart Study (JHS) is supported and conducted in collaboration with Jackson State University (HHSN268201800013I), Tougaloo College (HHSN268201800014I), the Mississippi State Department of Health (HHSN268201800015I) and the University of Mississippi Medical Center (HHSN268201800010I, HHSN268201800011I and HHSN268201800012I) contracts from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute for Minority Health and Health Disparities (NIMHD). The Melbourne Collaborative Cohort Study (MCCS) recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further augmented by Australian National Health and Medical Research Council grants 209057, 396414 and 1074383 and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database. The Multi-Ethnic Study of Atherosclerosis was supported by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040 and UL1-TR-001079 from NCRR. The Population Study of Women in Gothenburg (PSWG) was financed in part by grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALFGBG-720201. VIVA Study received grants 95/0029 and 06/90270 from the Instituto de Salud Carlos III, Spain.