Journal article

The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis

Hong Min Ng, Nada Slakeski, Catherine A Butler, Paul D Veith, Yu-Yen Chen, Sze Wei Liu, Brigitte Hoffmann, Stuart G Dashper, Eric C Reynolds

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | FRONTIERS MEDIA SA | Published : 2019

Abstract

Chronic periodontitis has a polymicrobial biofilm etiology and interactions between key oral bacterial species, such as Porphyromonas gingivalis and Treponema denticola contribute to disease progression. P. gingivalis and T. denticola are co-localized in subgingival plaque and have been previously shown to exhibit strong synergy in growth, biofilm formation and virulence in an animal model of disease. The motility of T. denticola, although not considered as a classic virulence factor, may be involved in synergistic biofilm development between P. gingivalis and T. denticola. We determined the role of T. denticola motility in polymicrobial biofilm development using an optimized transformation ..

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