Separating Probability and Reversal Learning in a Novel Probabilistic Reversal Learning Task for Mice
Jeremy A Metha, Maddison L Brian, Sara Oberrauch, Samuel A Barnes, Travis J Featherby, Peter Bossaerts, Carsten Murawski, Daniel Hoyer, Laura H Jacobson
Frontiers in Behavioral Neuroscience | Frontiers Media SA | Published : 2020
The exploration/exploitation tradeoff – pursuing a known reward vs. sampling from lesser known options in the hope of finding a better payoff – is a fundamental aspect of learning and decision making. In humans, this has been studied using multi-armed bandit tasks. The same processes have also been studied using simplified probabilistic reversal learning (PRL) tasks with binary choices. Our investigations suggest that protocols previously used to explore PRL in mice may prove beyond their cognitive capacities, with animals performing at a no-better-than-chance level. We sought a novel probabilistic learning task to improve behavioral responding in mice, whilst allowing the investigation of t..View full abstract
Awarded by Alzheimer's Association
Awarded by National Health and Medical Research Council
Awarded by National Institute of Mental Health
LJ and DH are supported by the Alzheimer's Association (2016NIRG-396905) and the National Health and Medical Research Council (APP1105284). The Florey Institute of Neuroscience and Mental Health acknowledge the support of the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. SB was supported by a National Institute of Mental Health grant (R01MH108653) and a NARSAD YIG. PB received funding from The University of Melbourne through the R@MAPprogram.