Journal article

Outcomes Six Months after Delivering 100% or 70% of Enteral Calorie Requirements during Critical Illness (TARGET) A Randomized Controlled Trial

Adam M Deane, Lorraine Little, Rinaldo Bellomo, Marianne J Chapman, Andrew R Davies, Suzie Ferrie, Michael Horowitz, Sally Hurford, Kylie Lange, Edward Litton, Diane Mackle, Stephanie O'Connor, Jane Parker, Sandra L Peake, Jeffrey J Presneill, Emma J Ridley, Vanessa Singh, Frank van Haren, Patricia Williams, Paul Young Show all

American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2020

Abstract

Rationale: The long-term effects of delivering approximately 100% of recommended calorie intake via the enteral route during critical illness compared with a lesser amount of calories are unknown.Objectives: Our hypotheses were that achieving approximately 100% of recommended calorie intake during critical illness would increase quality-of-life scores, return to work, and key life activities and reduce death and disability 6 months later.Methods: We conducted a multicenter, blinded, parallel group, randomized clinical trial, with 3,957 mechanically ventilated critically ill adults allocated to energy-dense (1.5 kcal/ml) or routine (1.0 kcal/ml) enteral nutrition.Measurements and Main Results..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Health Research Council (HRC) of New Zealand


Funding Acknowledgements

Supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (Project grant no. 1078026) and the Health Research Council (HRC) of New Zealand (Project grant no. 15/141). In-kind support provided by Fresenius Kabi Deutschland GmbH for the supply and delivery of study enteral nutrition. A.M.D. is supported by an NHMRC Career Development Fellowship. E.L. is supported by an NHMRC Early Career Fellowship.