Journal article

In vitro study of pharmacobezoar formation in simulated acetaminophen overdose

Yu Kwan Li, Ka Fung Lam, Cheung Lun William Wong, Anselm Wong

Clinical Toxicology | TAYLOR & FRANCIS LTD | Published : 2019

Abstract

Objectives: There have been few studies of pharmacobezoar formation, but they can be an important contributor to overdose toxicity. Pharmacobezoars may explain the delayed peak or "double hump" pharmacokinetics, which were noted in previous case reports with delayed toxicity of acetaminophen (APAP). We validated the presence of APAP bezoar formation in a controlled modified in vitro environment simulating acute APAP overdose.Methods: This study involved the APAP and control groups (ferrous sulfate and chlorpheniramine). The APAP study group contained three subgroups of APAP with different dosage, i.e., 25 g (50 tabs)/37.5 g (75 tabs)/50 g (100 tabs). The positive control group containing fer..

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University of Melbourne Researchers