Effects of chronic silencing of relaxin-3 production in nucleus incertus neurons on food intake, body weight, anxiety-like behaviour and limbic brain activity in female rats
Camila de Avila, Sandrine Chometton, Sherie Ma, Lola Torz Pedersen, Elena Timofeeva, Carlo Cifani, Andrew L Gundlach
PSYCHOPHARMACOLOGY | SPRINGER | Published : 2020
Eating disorders are frequently triggered by stress and are more prevalent in women than men. First signs often appear during early adolescence, but the biological basis for the sex-specific differences is unknown. Central administration of native relaxin-3 (RLN3) peptide or chimeric/truncated analogues produces differential effects on food intake and HPA axis activity in adult male and female rats, but the precise role of endogenous RLN3 signalling in metabolic and neuroendocrine control is unclear. Therefore, we examined the effects of microRNA-induced depletion (knock-down) of RLN3 mRNA/(peptide) production in neurons of the brainstem nucleus incertus (NI) in female rats on a range of phy..View full abstract
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Awarded by NHMRC (Australia)
This research was supported by NHMRC (Australia) project grant 1067522 (ALG), a NARSAD Independent Investigator Award (ALG), and a grant from the Dorothy Levien Foundation (ALG). CDA was supported by scholarships from the Centre thematique de recherche en neurosciences and Fonds de recherche du Quebec - Sante, and by a Commonwealth Government (Australia) Endeavour Research Fellowship. We also acknowledge financial support from the Victorian State Government Infrastructure Program to The Florey Institute of Neuroscience and Mental Health.