Journal article

Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan

Danielle Hiam, Cassandra Smith, Sarah Voisin, Josh Denham, Xu Yan, Shanie Landen, Macsue Jacques, Javier Alvarez-Romero, Andrew Garnham, Mary N Woessner, Markus Herrmann, Gustavo Duque, Itamar Levinger, Nir Eynon

AGING-US | IMPACT JOURNALS LLC | Published : 2020

Abstract

A reduction in aerobic capacity and the shortening of telomeres are hallmarks of the ageing process. We examined whether a lower aerobic capacity is associated with shorter TL in skeletal muscle and/or leukocytes, across a wide age range of individuals. We also tested whether TL in human skeletal muscle (MTL) correlates with TL in leukocytes (LTL). Eighty-two recreationally active, healthy men from the Gene SMART cohort (31.4±8.2 years; body mass index (BMI)=25.3±3.3kg/m2), and 11 community dwelling older men (74.2±7.5years-old; BMI=28.7±2.8kg/m2) participated in the study. Leukocytes and skeletal muscle samples were collected at rest. Relative telomere length (T/S ratio) was measured by RT-..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council, Australia (NHMRC CDF)


Awarded by National Health and Medical Research Council, Australia (NHMRC ECF)


Funding Acknowledgements

N.E. supported by a Career Development Fellowship from the National Health and Medical Research Council, Australia (NHMRC CDF#APP1140644). S.V. is supported by an Early Career Fellowship from the National Health and Medical Research Council, Australia (NHMRC ECF#APP1157732).