Prevalence and associations of larger burden of intra-anal high-grade squamous intraepithelial lesions at baseline in an Australian cohort of gay and bisexual men: The Study of the Prevention of Anal Cancer
DJ Templeton, C Williamson, F Jin, RJ Hillman, JM Roberts, C Law, CK Fairley, SM Garland, AE Grulich, IM Poynten
Cancer Epidemiology | ELSEVIER SCI LTD | Published : 2020
OBJECTIVES: To investigate factors associated with larger burden of intra-anal high-grade squamous intraepithelial lesions (HSIL) in a natural history study of HSIL. METHODS: 617 gay and bisexual men (GBM) attended a baseline visit. High-resolution anoscopy-directed biopsy was performed of suspected HSIL. GBM with biopsy-confirmed HSIL (bHSIL) affecting a single-octant were compared with those who had bHSIL affecting a larger area. RESULTS: Of 196 men with bHSIL at baseline, 73 (37.2 %) had larger bHSIL burden. Larger burden was independently associated with anal HPV16 detection (aOR 2.06, 95 % CI 1.09-3.89, p = 0.026) and infection with a greater number of high-risk HPV types (aOR per type ..View full abstract
Awarded by National Health and Medical Research Council
Awarded by Cancer Council of New South Wales
The SPANC study was supported by the National Health and Medical Research Council (Grant number 568971) and the Cancer Council of New South Wales (Grant number 13-11). Cytologic testing materials were provided by Hologic Pty Ltd. The Kirby Institute is affiliated with the Faculty of Medicine, University of New South Wales, and funded by the Australian Government of Health and Ageing.