Journal article

Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells

Antonio Celentano, Tami Yap, Rita Paolini, Callisthenis Yiannis, Michiko Mirams, Kendrick Koo, Michael McCullough, Nicola Cirillo

JOURNAL OF ORAL PATHOLOGY & MEDICINE | WILEY | Published : 2021

Abstract

BACKGROUND: Matrix metalloproteinases (MMPs) play a crucial role in the malignant phenotype of cancer cells. In particular, active levels of MMP2 in cancer cells have been associated with invasion and metastasis through the degradation of basement membrane extracellular matrix proteins. However, little is known about the role of this potential biomarker in oral cancer. Our aim was to investigate the effect of MMP2 inhibition on OSCC activity in vitro, as well as to assess MMP2 dysregulation in oral cancer samples. METHODS: Human OSCC cell lines H357 and H400 were tested with the selective MMP2 inhibitor ARP101 and the MMP2 neutralising monoclonal antibody MA5-13590 to assess cell proliferati..

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