JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression
Katie L Owen, Natasha K Brockwell, Belinda S Parker
CANCERS | MDPI | Published : 2019
Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates almost all immune regulatory processes, including those that are involved in tumor cell recognition and tumor-driven immune escape. Antitumor immune responses are largely driven by STAT1 and STAT2 induction of type I and II interferons (IFNs) and the downstream programs IFNs potentiate. Conversely, STAT3 has been widely linked to cancer cell survival, immunosuppression, and sustained inflammation in the tumor microenvironment. The discovery of JAK-STAT cross-regulatory mechanisms, post-translational control, and non-canonical signal transduction has added a new level of complexity to JAK-STAT governan..View full abstract
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Awarded by Victorian Cancer Agency
This research was funded by fellowship funding to B.S.P. (Victorian Cancer Agency, MCRF16022) and grant support from Movember (PCRA, PRECEPT) and PCFA/Movember (MRTA, ProMis).