Long-Term Motor Deficit and Diffuse Cortical Atrophy Following Focal Cortical Ischemia in Athymic Rats
Charlotte M Ermine, Fahad Somaa, Ting-Yi Wang, Brett J Kagan, Clare L Parish, Lachlan H Thompson
Frontiers in Cellular Neuroscience | FRONTIERS MEDIA SA | Published : 2019
Development of new stroke therapies requires animal models that recapitulate the pathophysiological and functional consequences of ischemic brain damage over time-frames relevant to the therapeutic intervention. This is particularly relevant for the rapidly developing area of stem cell therapies, where functional replacement of circuitry will require maturation of transplanted human cells over months. An additional challenge is the establishment of models of ischemia with stable behavioral phenotypes in chronically immune-suppressed animals to allow for long-term survival of human cell grafts. Here we report that microinjection of endothelin-1 into the sensorimotor cortex of athymic rats res..View full abstract
Awarded by NHMRC
CP was an NHMRC senior research fellow. This work was supported by the NHMRC project grant #1042584. The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.