Journal article

Risk stratification in children with cancer and febrile neutropenia: A national, prospective, multicentre validation of nine clinical decision rules

Gabrielle M Haeusler, Karin A Thursky, Monica A Slavin, Franz E Babl, Richard De Abreu Lourenco, Zoe Allaway, Francoise Mechinaud, Robert Phillips, undefined Australian PICNICC study group and the PREDICT network

EClinicalMedicine | Lancet | Published : 2020

Abstract

Background: Reduced intensity treatment of low-risk febrile neutropenia (FN) in children with cancer is safe and improves quality of life. Identifying children with low-risk FN using a validated risk stratification strategy is recommended. This study prospectively validated nine FN clinical decision rules (CDRs) designed to predict infection or adverse outcome. Methods: Data were collected on consecutive FN episodes in this multicentre, prospective validation study. The reproducibility and discriminatory ability of each CDR in the validation cohort was compared to the derivation dataset and details of missed outcomes were reported. Findings: There were 858 FN episodes in 462 patients from ei..

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Grants

Awarded by Medical Research Council


Awarded by Department of Health


Funding Acknowledgements

This study was funded by National Health and Medical Research Council (NHMRC) Project Grant (APP1104527). We gratefully acknowledge the support and endorsement of the Australian and New Zealand Children's Haematology/Oncology Group (ANZCHOG) and the Paediatric Research in Emergency Departments International Collaborative (PREDICT).