Journal article

Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections

Stefano G Giulieri, Steven YC Tong, Deborah A Williamson

Microbial Genomics | MICROBIOLOGY SOC | Published : 2020

Abstract

Resistance to meticillin and vancomycin in Staphylococcus aureus significantly complicates the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here, we review the molecular mechanisms and genomic epidemiology of resistance to these agents, with a focus on how genomics has provided insights into the emergence and evolution of major meticillin-resistant S. aureus clones. We also provide insights on the use of bacterial whole-genome sequencing to inform management of S. aureus infections and for control of transmission at the hospital and in the community.

Grants

Awarded by Career Development Fellowship from the National Health and Medical Research Council (NHMRC) of Australia


Awarded by Early Career Fellowship from the NHMRC of Australia


Funding Acknowledgements

S.Y.C.T. (grant no. 1145033) was supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC) of Australia. D.A.W. (grant no. GNT1123854) was supported by an Early Career Fellowship from the NHMRC of Australia.