Journal article
Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition
Yi Ju, Christina Cortez-Jugo, Jingqu Chen, Ting-Yi Wang, Andrew J Mitchell, Evelyn Tsantikos, Nadja Bertleff-Zieschang, Yu-Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L Hibbs, Leslie Y Yeo, Christoph E Hagemeyer, Frank Caruso
Advanced Science | John Wiley & Sons | Published : 2020
Abstract
Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the efficacy of encapsulated inhaled drugs. This study describes the nanoengineering and nebulization of metal–phenolic capsules as pulmonary carriers of small molecule drugs and macromolecular drugs in lung cell lines, a human lung model, and mice. Tuning the aerodynamic diameter by increasing the capsule shell thickness (from ≈100 to 200 nm in increments of ≈50 nm) through repeated film deposition on a sacrificial template allows precise control of ..
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Grants
Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC Senior Principal Research Fellowship
Awarded by NHMRC Research Fellowship
Awarded by Australian National Health and Medical Research Council
Funding Acknowledgements
This work was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036) and through an ARC Discovery Project Scheme (DP170103331). This work was also funded by the National Health and Medical Research Council (NHMRC, Project Grant GNT1120129, C.E.H.). F.C. acknowledges the award of an NHMRC Senior Principal Research Fellowship (GNT1135806). C.E.H. acknowledges the award of an NHMRC Research Fellowship (GNT1154270). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). Transmission electron microscopy analyses were conducted using the facilities at Bio21 Advanced Microscopy Facility, The University of Melbourne. Scanning electron microscopy analyses were performed using the facilities at Biosciences Microscopy Unit, School of Bioscience, The University of Melbourne. The authors acknowledge the Monash Histology Platform and the AMREP Flow Cytometry Core Facility for the use of the AMNIS Instrument, in particular Eva OrlowskiOliver for her assistance in data acquisition. The authors acknowledge the Melbourne TrACEES Platform (Trace Analysis for Chemical, Earth, and Environmental Sciences) for technical support, and Dr. Xiaofei Alex Duan for the XPS data processing and analysis. The authors thank Dr. Shanyuanye Guan and Jiao Song for assistance with preparing schematic illustrations, and Prof. Magdalena Plebanski, Dr. Danzi Song, and Dr. Joseph J. Richardson for helpful discussions. All animal procedures were conducted in accordance with the Australian National Health and Medical Research Council's published Code of Practice for the Use of Animals in Research, and experiments were approved by the Alfred Medical Research and Education Precinct (AMREP) Animal Ethics Committee (E/1625/2016/M).