Journal article

A practical guide to laboratory investigations at diagnosis and follow up in Waldenstrom macroglobulinaemia: recommendations from the Medical and Scientific Advisory Group, Myeloma Australia, the Pathology Sub-committee of the Lymphoma and Related Diseases Registry and the Australasian Association of Clinical Biochemists Monoclonal Gammopathy Working Group

M Gohar Maqbool, Constantine S Tam, Ian M Morison, David Simpson, Peter Mollee, Hans Schneider, Henry Chan, Surender Juneja, Yasmin Harvey, Lakshmi Nath, Pravin Hissaria, H Miles Prince, Helen Wordsworth, Stephen Opat, Dipti Talaulikar

PATHOLOGY | ELSEVIER | Published : 2020

Abstract

Waldenström macroglobulinaemia (WM) is an indolent non-Hodgkin lymphoma which usually presents with symptoms related to infiltration of bone marrow or other tissues like lymph nodes, liver or spleen and has certain unusual clinical manifestations, e.g., renal and central nervous system (CNS) involvement. It also has an array of laboratory features including hypersecretion of IgM, cryoglobulinaemia, increased plasma viscosity and identification of mutated MYD88L265P in more than 90% of cases. In this review, we aim to provide a guide to the laboratory investigations recommended for WM at initial diagnosis and at follow-up. A discussion on the nuances of diagnosis and differential diagnoses is..

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