Neuromyelitis Optica Spectrum Disorder and Anti-Aquaporin 4 Channel Immunoglobulin in an Australian Pediatric Demyelination Cohort
Ariel Dahan, Fabienne Brilot, Richard Leventer, Andrew J Kornberg, Russell C Dale, Eppie M Yiu
Journal of Child Neurology | SAGE PUBLICATIONS INC | Published : 2020
Neuromyelitis optica spectrum disorder is uncommon in children, and often seronegative for aquaporin-4 immunoglobulin G (AQP4-IgG). We conducted a retrospective study of 67 children presenting to a single Australian center with acquired demyelinating syndromes over a 7-year period. All patients were tested for AQP4-IgG. Five children (7.5%) had neuromyelitis optica spectrum disorder. One child was seropositive for AQP4-IgG (1.5%) and had a relapsing disease course with mild residual deficits. She also had a concomitant motor axonal neuropathy that improved with immunosuppressive therapy. Of the remaining 4 children, 3 had a monophasic course and 1 a relapsing course. Two were tested for anti..View full abstract
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: EMY is supported by a NHMRC Early Career Fellowship. RCD is supported by a NHMRC Practitioner Fellowship. RCD and FB receive research support from the NHMRC and Multiple Sclerosis Research Australia. RJL is supported by a Melbourne Children's Clinician Scientist Fellowship.