Journal article

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products

Sarah Nicolai, Marcin Wegrecki, Tan-Yun Cheng, Elvire A Bourgeois, Rachel N Cotton, Jacob A Mayfield, Gwennaelle C Monnot, Jerome Le Nours, Ildiko Van Rhijn, Jamie Rossjohn, D Branch Moody, Annemieke de Jong

Science Immunology | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2020

Abstract

During industrialization, humans have been exposed to increasing numbers of foreign chemicals. Failure of the immune system to tolerate drugs, cosmetics, and other skin products causes allergic contact dermatitis, a T cell-mediated disease with rising prevalence. Models of αβ T cell response emphasize T cell receptor (TCR) contact with peptide-MHC complexes, but this model cannot readily explain activation by most contact dermatitis allergens, which are nonpeptidic molecules. We tested whether CD1a, an abundant MHC I-like protein in human skin, mediates contact allergen recognition. Using CD1a-autoreactive human αβ T cell clones to screen clinically important allergens present in skin patch ..

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University of Melbourne Researchers

Grants

Awarded by NIH


Awarded by Australian Research Council (ARC)


Awarded by ARC Future Fellowship


Awarded by Office of the Director, NIH


Funding Acknowledgements

S.N. was supported by an NIH training grant (T32 AI007306) and is currently employed by HealthPartners, St. Paul, Minnesota. A.d.J. is supported by a K01 award from the NIH (K01 AR068475) and an Irving Scholarship from the Irving Institute for Clinical and Translational Research at Columbia University. D. B.M. is supported by the NIH (R01 AR048632) and the Wellcome Trust Collaborative Award. This work was supported by the National Health and Medical Research Council of Australia (NHMRC) and the Australian Research Council (ARC) (CE140100011). J.L.N. is supported by an ARC Future Fellowship (FT160100074); J.R. is supported by an Australian ARC Laureate Fellowship and the Wellcome Trust Collaborative Award. Research reported in this publication was performed in the CCTI Flow Cytometry Core, supported, in part, by the Office of the Director, NIH under award S10OD020056.