Journal article

Influenza Vaccine Effectiveness Against Influenza-Related Mortality in Australian Hospitalized Patients: A Propensity Score Analysis

Monica L Nation, Robert Moss, Matthew J Spittal, Tom Kotsimbos, Paul M Kelly, Allen C Cheng

CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2021

Abstract

BACKGROUND: Data on influenza vaccine effectiveness (IVE) against mortality are limited, with no Australian data to guide vaccine uptake. We aimed to assess IVE against influenza-related mortality in Australian hospitalized patients, assess residual confounding in the association between influenza vaccination and mortality, and assess whether influenza vaccination reduces the severity of influenza illness. METHODS: Data were collected between 2010 and 2017 from a national Australian hospital-based sentinel surveillance system using a case-control design. Adults and children admitted to the 17 study hospitals with acute respiratory symptoms were tested for influenza using nucleic acid testing..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Career Development Fellowship


Awarded by Australian Research Council Future Fellowship


Funding Acknowledgements

FluCAN and PAEDS are supported by the Australian Department of Health. A. C. C. was supported by a National Health and Medical Research Council (NHMRC) Career Development Fellowship (APP1068732). Several sites are also funded by an NHMRC Partnership Grant. M. J. S. is a recipient of an Australian Research Council Future Fellowship (project number FT180100075).