Mitochondrial DNA Copy-Number Variation and Pancreatic Cancer Risk in the Prospective EPIC Cohort
Manuel Gentiluomo, Verena A Katzke, Rudolf Kaaks, Anne Tjonneland, Gianluca Severi, Vittorio Perduca, Marie-Christine Boutron-Ruault, Elisabete Weiderpass, Pietro Ferrari, Theron Johnson, Matthias B Schulze, Manuela Bergmann, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote Show all
Cancer Epidemiology Biomarkers & Prevention | AMER ASSOC CANCER RESEARCH | Published : 2020
BACKGROUND: Mitochondrial DNA (mtDNA) copy number in peripheral blood has been found to be associated with risk of developing several cancers. However, data on pancreatic ductal adenocarcinoma (PDAC) are very limited. METHODS: To further our knowledge on this topic, we measured relative mtDNA copy number by a quantitative real-time PCR assay in peripheral leukocyte samples of 476 PDAC cases and 357 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. RESULTS: We observed lower mtDNA copy number with advancing age (P = 6.54 × 10-5) and with a high body mass index (BMI) level (P = 0.004) and no association with sex, smoking behavior, and alcoho..View full abstract
Awarded by Cancer Research UK
Awarded by Medical Research Council UK
We thank the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, for their contribution and ongoing support to the EPIC Study. This work was partially supported by intramural funds of University of Pisa and DKFZ, by Fondazione Tizzi, and by Fondazione Arpa (www.fondazionearpa.it).The EPIC-Potsdam study was funded by the Federal Ministry of Education and Research (Germany), the German Cancer Aid, the German Cancer Research Center, and the German Institute of Human Nutrition Potsdam-Rehbrucke. EPIC-Oxford was supported by Cancer Research UK (C8221/A19170) and the Medical Research Council UK (MR/M012190/1). EPIC-Greece was supported by the Hellenic Health Foundation.