Journal article

Pharmacological Mechanisms Involved in Sensory Gating Disruption Induced by ( /-)-3,4-Methylene- Dioxymethamphetamine (MDMA): Relevance to Schizophrenia

Jaime Lee, Shane Thwaites, Andrea Gogos, Maarten van den Buuse

Brain Sciences | MDPI | Published : 2020

Abstract

Sensory gating deficits have been demonstrated in schizophrenia, but the mechanisms involved remain unclear. In the present study, we used disruption of paired-pulse gating of evoked potentials in rats by the administration of (±)-3,4-methylene-dioxymethamphetamine (MDMA) to study serotonergic and dopaminergic mechanisms involved in auditory sensory gating deficits. Male Sprague-Dawley rats were instrumented with cortical surface electrodes to record evoked potential changes in response to pairs of 85dB tones (S1 and S2), 500msec apart. Administration of MDMA eliminated the normal reduction in the amplitude of S2 compared to S1, representing disruption of auditory sensory gating. Pretreatmen..

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Grants

Funding Acknowledgements

S.T. was a recipient of an Australian Postgraduate Award. At the time of these studies, A.G. was supported by a Discovery Early Career Researcher Award from the Australian Research Council (ARC) and M.v.d.B. was supported by a Senior Research Fellowship from the National Health and Medical Research Council of Australia (NHMRC).