Journal article

Effect of Midazolam in Addition to Propofol and Opiate Sedation on the Quality of Recovery After Colonoscopy: A Randomized Clinical Trial

Usha Gurunathan, Tony Rahman, Zelda Williams, Ann Vandeleur, Sweta Sriram, Jennifer Harch, Stuart Boggett, Cindy Hill, Andrea Bowyer, Colin Royse

Anesthesia & Analgesia | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020


BACKGROUND: There is a concern that midazolam, when used as a component of sedation for colonoscopy, may impair cognition and prolong recovery. We aimed to identify whether midazolam produced short- and longer-term effects on multiple dimensions of recovery including cognition. METHODS: A 2-center double-blinded, placebo-controlled, parallel-group, randomized, phase IV study with a 1:1 allocation ratio was conducted in adults ≥18 years of age undergoing elective outpatient colonoscopy, with sufficient English language proficiency to complete the Postoperative Quality of Recovery Scale (PostopQRS). Participants were administered either midazolam (0.04 mg·kg) or an equivalent volume of 0.9% sa..

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