The role of microglia in neuroprogressive disorders: mechanisms and possible neurotherapeutic effects of induced ketosis
Gerwyn Morris, Basant K Puri, Michael Maes, Lisa Olive, Michael Berk, Andre F Carvalho
Progress in Neuro-Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020
A comprehensive review of molecular mechanisms involved in the promotion and maintenance of distinct microglia phenotypes is provided. The acquisition and perpetuation of predominantly pro-inflammatory microglial phenotypes have been implicated in the pathophysiology of several neuroprogressive diseases and is associated with reduced ATP production via oxidative phosphorylation, increased ATP generation by glycolysis, elevated oxidative and nitrosative stress and other metabolic, inflammatory and hormonal insults. Microglia can also adopt a predominantly anti-inflammatory phenotypes with neuroprotective properties. Strategies that promote and maintain a predominantly anti-inflammatory phenot..View full abstract
Awarded by NHMRC
MB is supported by a NHMRC Senior Principal Research Fellowship 1059660 and 1156072. We thank Myrela Machado, M.D., pH.D. for assistance in the conceptualization and drafting of the figures.