Drug-resistant enteric fever worldwide, 1990 to 2018: a systematic review and meta-analysis
Annie J Browne, Bahar H Kashef Hamadani, Emmanuelle AP Kumaran, Puja Rao, Joshua Longbottom, Eli Harriss, Catrin E Moore, Susanna Dunachie, Buddha Basnyat, Stephen Baker, Alan D Lopez, Nicholas PJ Day, Simon I Hay, Christiane Dolecek
BMC Medicine | BMC | Published : 2020
BACKGROUND: Antimicrobial resistance (AMR) is an increasing threat to global health. There are > 14 million cases of enteric fever every year and > 135,000 deaths. The disease is primarily controlled by antimicrobial treatment, but this is becoming increasingly difficult due to AMR. Our objectives were to assess the prevalence and geographic distribution of AMR in Salmonella enterica serovars Typhi and Paratyphi A infections globally, to evaluate the extent of the problem, and to facilitate the creation of geospatial maps of AMR prevalence to help targeted public health intervention. METHODS: We performed a systematic review of the literature by searching seven databases for studies publishe..View full abstract
Awarded by Wellcome Trust
Awarded by Bill and Melinda Gates Foundation
This work was supported by the UK Department of Health and Social Care, Fleming Fund, the Wellcome Trust (209142/Z/17/Z), the Bill and Melinda Gates Foundation (OPP1176062) and the Li Ka Shing - Oxford Global Health Programme. The funder of this study had no role in the study design, data collecYYtion, data analysis, data interpretation or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.