Journal article

Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation The PEPTIC Randomized Clinical Trial

Paul J Young, Sean M Bagshaw, Andrew B Forbes, Alistair D Nichol, Stephen E Wright, Michael Bailey, Rinaldo Bellomo, Richard Beasley, Kathy Brickell, Glenn M Eastwood, David J Gattas, Frank Van Haren, Edward Litton, Diane M Mackle, Colin J McArthur, Shay P McGuinness, Paul R Mouncey, Leanlove Navarra, Dawn Opgenorth, David Pilcher Show all

JAMA | AMER MEDICAL ASSOC | Published : 2020


Importance: Proton pump inhibitors (PPIs) or histamine-2 receptor blockers (H2RBs) are often prescribed for patients as stress ulcer prophylaxis drugs in the intensive care unit (ICU). The comparative effect of these drugs on mortality is unknown. Objective: To compare in-hospital mortality rates using PPIs vs H2RBs for stress ulcer prophylaxis. Design, Setting, and Participants: Cluster crossover randomized clinical trial conducted at 50 ICUs in 5 countries between August 2016 and January 2019. Patients requiring invasive mechanical ventilation within 24 hours of ICU admission were followed up for 90 days at the hospital. Interventions: Two stress ulcer prophylaxis strategies were compared ..

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Funding Acknowledgements

Funded by the Health Research Council of New Zealand, the Canadian Institutes of Health Research, the Australian and New Zealand Intensive Care Foundation, and the Health Research Board of Ireland. The PEPTIC trial was supported by the UK National Institute for Health Research Critical Care Clinical Research Networks and the UK Critical Care Research Group.