Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer (vol 31, pg 103, 2020)
JM Genkinger, K Wu, M Wang, D Albanes, A Black, PA van den Brandt, KA Burke, MB Cook, SM Gapstur, GG Giles, E Giovannucci, GG Goodman, PJ Goodman, N Hakansson, TJ Key, S Mannisto, L Le Marchand, LM Liao, RJ MacInnis, ML Neuhouser Show all
ANNALS OF ONCOLOGY | ELSEVIER | Published : 2021
BACKGROUND: Advanced prostate cancer etiology is poorly understood. Few studies have examined associations of anthropometric factors (e.g. early adulthood obesity) with advanced prostate cancer risk. PATIENTS AND METHODS: We carried out pooled analyses to examine associations between body fatness, height, and prostate cancer risk. Among 830 772 men, 51 734 incident prostate cancer cases were identified, including 4762 advanced (T4/N1/M1 or prostate cancer deaths) cases, 2915 advanced restricted (same as advanced, but excluding localized cancers that resulted in death) cases, 9489 high-grade cases, and 3027 prostate cancer deaths. Cox proportional hazards models were used to calculate study-s..View full abstract
Awarded by National Cancer Institute at the National Institutes of Health
The centralization, checking, harmonization, and statistical analyses of the participant level data from each of the cohorts were supported by the National Cancer Institute at the National Institutes of Health grants CA098566 and CA55075, and by grant 2009/89 from the World Cancer Research Fund International. Funding for the participating cohorts is included in supplementary Table S3, available at Annals of Oncology online.