Focal Ventricular Tachycardias in Structural Heart Disease Prevalence, Characteristics, and Clinical Outcomes After Catheter Ablation
Robert D Anderson, Geoffrey Lee, Ivana Trivic, Timothy Campbell, Timmy Pham, Chrishan Nalliah, Eddy Kizana, Stuart P Thomas, Siddharth J Trivedi, Troy Watts, Jonathan Kalman, Saurabh Kumar
JACC Clinical Electrophysiology | ELSEVIER | Published : 2020
OBJECTIVES: This study sought to summarize the procedural characteristics and outcomes of patients with structural heart disease (SHD) who have focal ventricular tachycardia (VT). BACKGROUND: Scar-mediated re-entry is the predominant mechanism of VT in SHD. Some SHD patients may have a focal VT mechanism that remains poorly described. METHODS: An extended induction protocol incorporating programmed electrical stimulation, right ventricular burst pacing and isoprenaline was used to elucidate both re-entrant and focal VT mechanisms. RESULTS: Eighteen of 112 patients (16%) with SHD undergoing VT ablation over 2 years had a focal VT mechanism elucidated (mean age 66±13 years; ejection fraction 4..View full abstract
Dr. Anderson has been supported by postgraduate scholarships co-funded by the National Health and Medical Research Council (NHMRC), National Heart Foundation (NHF), and Royal Australasian College of Physicians NHMRC Woodcock Scholarships. Dr. Campbell was a former employee of Johnson and Johnson Medical within the last 12 months; and was a previously salaried employee of Johnson and Johnson Medical. Dr. Kalman has received fellowship support from Biosense Webster, Medtronic, and Abbott. Dr. Kumar has received research grants from Biotronik, Abbott, Bayer-Cardiac Society of Australia and New Zealand, Perpetual Ramaciotti Foundation, Sylvia and Charles Viertel Foundation, Westmead Hospital Charitable Trust, and Westmead Hospital Research and Education Network; has received honoraria from Abbott Medical, Biosense Webster, Biotronik, and Sanofi; and has received fellowship support from NSW Early to Mid Career Fellowship. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Francis Marchlinski, MD, served as Guest Editor for this paper.