Local heroes or villains: tissue-resident memory T cells in human health and disease
SC Sasson, CL Gordon, SN Christo, P Klenerman, LK Mackay
CELLULAR & MOLECULAR IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2020
Tissue-resident memory T (TRM) cells are increasingly associated with the outcomes of health and disease. TRM cells can mediate local immune protection against infections and cancer, which has led to interest in TRM cells as targets for vaccination and immunotherapies. However, these cells have also been implicated in mediating detrimental pro-inflammatory responses in autoimmune skin diseases such as psoriasis, alopecia areata, and vitiligo. Here, we summarize the biology of TRM cells established in animal models and in translational human studies. We review the beneficial effects of TRM cells in mediating protective responses against infection and cancer and the adverse role of TRM cells i..View full abstract
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Awarded by NIHR
S.C.S. is supported by an Oxford-Celgene Postdoctoral Fellowship. C.L.G. is supported by an NHMRC Early Career Fellowship (GNT 1160963). P.K. is supported by an Oxford and NIHR Senior Fellowship (WT10966MA). L.K.M. is a Senior Medical Research Fellow supported by the Sylvia and Charles Viertel Charitable Foundation.