Conference Proceedings
MACROLIDE AND FLUOROQUINOLONE RESISTANCE-ASSOCIATED MUTATIONS IN MYCOPLASMA GENITALIUM: A SYSTEMATIC REVIEW AND META-ANALYSIS
Dorothy Machalek, Yusha Tao, Hannah Shilling, Jorgen Jensen, Magnus Unemo, Gerald Murray, Eric Chow, Nicola Low, Suzanne Garland, Christopher Fairley, Lenka Vodstrcil, Jane Hocking, Lei Zhang, Catriona Bradshaw
SEXUALLY TRANSMITTED INFECTIONS | BMJ PUBLISHING GROUP | Published : 2019
Abstract
Treatment for Mycoplasma genitalium is becoming increasingly complicated by antimicrobial resistance. We summarised published global data on the prevalence of macrolide and fluoroquinolone resistance-associated mutations in M. genitalium and examined trends over time. We searched PubMed, EMBASE and Medline until December 31, 2017. We included studies that reported the percentage of key mutations associated with macrolide resistance (23S rRNA gene: A2071C/G/T; A2072C/G/T) and/or fluoroquinolone failure (parC gene: S83R/I; D87N/Y) among M. genitalium positive specimens. Data were extracted by geographic region, collection year, sex, and risk group (men who have sex with men [MSM] or heterosexu..
View full abstract