Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment
Arianna Cembran, Kiara F Bruggeman, Richard J Williams, Clare L Parish, David R Nisbet
iScience | CELL PRESS | Published : 2020
The brain is a complex 3-dimensional structure, the organization of which provides a local environment that directly influences the survival, proliferation, differentiation, migration, and plasticity of neurons. To probe the effects of damage and disease on these cells, a synthetic environment is needed. Three-dimensional culturing of stem cells, neural progenitors, and neurons within fabricated biomaterials has demonstrated superior biomimetic properties over conventional 2-dimensional cultureware, offering direct recapitulation of both cell-cell and cell-extracellular matrix interactions. Within this review we address the benefits of deploying biomaterials as advanced cell culture tools ca..View full abstract
C.L.P. is supported by a Senior Research Fellowship provided by the National Health and Medical Research Council (NHMRC) Australia. D.R.N. holds an NHMRC Australia Dementia Research Leadership Fellowship.