Journal article

Copper-Catalyzed Oxidative Cross-Coupling of Sulfoximines and Alkynes

Long Wang, He Huang, Daniel L Priebbenow, Fang-Fang Pan, Carsten Bolm

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | WILEY-V C H VERLAG GMBH | Published : 2013

Abstract

A 'Cu'te couple: A synthetically useful protocol for the preparation of N-alkynylated sulfoximines (yne sulfoximines) has been developed. The method involves a mild copper-catalyzed oxidative cross-coupling of NH-sulfoximines and terminal alkynes (see scheme). The corresponding N-acyl sulfoximines were also obtained selectively after acid-catalyzed hydrolysis of the yne sulfoximines. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

University of Melbourne Researchers

Grants

Funding Acknowledgements

This work was supported by the German-Israeli Foundation (G. I. F.). D. L. P. acknowledges support by the Alexander von Humboldt foundation. We also thank Prof. Dr. Jiang Cheng (Changzhou University, China) for helpful discussions.