The Disubstitution of Acetals to Prepare ,-Bis(aryl) -Keto Esters

Abstract

An efficient catalytic protocol for the synthesis of δ,δ- bis(aryl)-substituted β-keto esters has been developed. This method involves the Lewis acid catalysed disubstitution reaction of ester-substituted silyl enol ether acetals with a series of aromatic nucleophiles to afford valuable functionalized β-keto esters with several sites available for further derivatisation. An efficient protocol for the conversion of silyl enol acetals into δ,δ-bis(aryl) β-keto esters was developed. In the presence of an aromatic nucleophile, activation of the acetal by a catalytic amount of Lewis acid facilitates the disubstitution reaction to afford a series of valuable functionalised β-keto esters. Copyright..