Journal article

MBCL-51. RETROSPECTIVE ANALYSIS OF VICTORIAN PATIENTS DIAGNOSED WITH MEDULLOBLASTOMA BETWEEN 1990-2017

S Khan, C White, PA Downie, J Hansford, CR Cochrane, A Szczepny, P Siswara, A Sexton-Oates, D McGregor, TB Phung, E Algar, JE Cain

Neuro-oncology | Oxford University Press (OUP) | Published : 2018

Abstract

Abstract BACKGROUND Medulloblastoma is the most common yet challenging paediatric brain tumour. No longer considered a single disease entity, medulloblastoma is comprised of at least four distinct genetically and molecularly defined subgroups. OBJECTIVES Retrospectively assess the performance and outcomes of all patients diagnosed with medulloblastoma between 1990-2017 according to molecular subgroups. METHODS After obtaining ethical approval, confirming sample adequacy, 76 samples (FFPE and Fresh Frozen) were retrieved from the two Victorian children’s oncology providers, Monash Children’s Hospital and The Royal Children’s Hospital. Blinded review of histology and immunohistochemistry using..

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