Human mucosal-associated invariant t cells in older individuals display expanded tcrαβ clonotypes with potent antimicrobial responses

L Loh; NA Gherardin; S Sant; L Grzelak; JC Crawford; NL Bird; HF Koay; CE Van De Sandt; ML Moreira; M Lappas; EK Allen; J Crowe; T Loudovaris; KL Flanagan; KM Quinn; J Rossjohn; PG Thomas; SBG Eckle; J McCluskey; DI Godfrey; K Kedzierska

Journal article

Human mucosal-associated invariant t cells in older individuals display expanded tcrαβ clonotypes with potent antimicrobial responses

L Loh, NA Gherardin, S Sant, L Grzelak, JC Crawford, NL Bird, HF Koay, CE Van De Sandt, ML Moreira, M Lappas, EK Allen, J Crowe, T Loudovaris, KL Flanagan, KM Quinn, J Rossjohn, PG Thomas, SBG Eckle, J McCluskey, DI Godfrey Show all

Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2020

DOI: 10.4049/jimmunol.1900774

Abstract

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to undergo marked numerical changes with age in humans, our understanding of how MAIT cells are altered during different phases across the human life span is largely unknown. Although also abundant in the tissues, our study focuses on MAIT cell analyses in blood. Across the human life span, we show that naive-like MAIT cells in umbilical cord blood switch to a central/effector memory-like profile that is sustained into older age. Whereas low-γrade levels of plasma cytokine/chemokine were apparent in older donors (>65 y old), surprisingly, they did not correlate with the..

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University of Melbourne Researchers

Liyen Loh Author

Nicholas Gherardin Author

Ludivine Grzelak Author

Fern Koay Author

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Grants

Awarded by University of Melbourne

Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NHMRC) Program Grant 1071916 (to K.K.), Program Grant 1113293 (to D.I.G.), and Project Grant 1140126 (to D.I.G.) and the Australian Research Council (ARC) (CE140100011). H.-F.K. is supported by an NHMRC Early Career Fellowship (1160333). K.K. is an NHMRC Senior Research Fellow (1102792), D.I.G. is supported by an NHMRC Senior Principal Research Fellowship (1117766), J.R. is an ARC Australian Laureate Fellow, and S.S. was supported by the Victoria India Doctoral Scholarship and The University of Melbourne International Fee Remission Scholarship. S.B.G.E. is an ARC Discovery Early Career Researcher Award Fellow (DE170100407). M.L. is supported by a research fellowship from the Department of Obstetrics and Gynaecology (The University of Melbourne) and a faculty fellowship from The University of Melbourne. C.E.v.d.S. has received funding from the European Union Horizon 2020 Research and Innovation Program under Marie Sklodowska-Curie Grant Agreement 792532. K.L.F. was awarded funding from The Clifford Craig Foundation.