Low-Fouling Fluoropolymers for Bioconjugation and In Vivo Tracking
Changkui Fu, Bans Demir, Sheilajen Alcantara, Vinod Kumar, Felicity Han, Hannah G Kelly, Xiao Tan, Ye Yu, Weizhi Xu, Jiacheng Zhao, Cheng Zhang, Hui Peng, Cyrille Boyer, Trent M Woodruff, Stephen J Kent, Debra J Searles, Andrew K Whittaker
Angewandte Chemie International Edition | WILEY-V C H VERLAG GMBH | Published : 2020
The conjugation of hydrophilic low-fouling polymers to therapeutic molecules and particles is an effective approach to improving their aqueous stability and solubility, and extending their pharmacokinetics. Recent concerns over the immunogenicity of poly(ethylene glycol) has highlighted the importance of identifying alternative low fouling polymers. Herein, we report a new class of synthetic water-soluble homo-fluoropolymers with a sulfoxide side-chain structure. The incorporation of fluorine enables direct imaging of the homopolymer by 19 F MRI, negating the need for additional synthetic steps to attach an imaging moiety. These self-reporting fluoropolymers show outstanding imaging sensitiv..View full abstract
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council
Awarded by University of Queensland
A.W. acknowledges the financial support from Australian Research Council (CE140100036, DP0987407, DFP110104299, DFP180101221, LE0775684, LE0668517, and LE0882357) and the National Health and Medical Research Council (APFP1021759). C.F. acknowledges the University of Queensland for a UQ Development Fellowship (UQFEL1831361). T.M.W. acknowledges support from the National Health and Medical Research Council (APP1118881 and APP1105420). B.D. and D.J.S. acknowledge support from the Queensland Cyber Infrastructure Foundation (QCIF) and the University of Queensland Research Computing Centre. The Australian National Fabrication Facility, Queensland Node, is also acknowledged for access to some items of equipment.