Journal article

The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Sadaf G Sepanlou, Saeid Safiri, Catherine Bisignano, Kevin S Ikuta, Shahin Merat, Mehdi Saberifiroozi, Hossein Poustchi, Derrick Tsoi, Danny V Colombara, Amir Abdoli, Rufus Adesoji Adedoyin, Mohsen Afarideh, Sutapa Agrawal, Sohail Ahmad, Elham Ahmadian, Ehsan Ahmadpour, Tomi Akinyemiju, Chisom Joyqueenet Akunna, Vahid Alipour, Amir Almasi-Hashiani Show all

The Lancet Gastroenterology & Hepatology | ELSEVIER INC | Published : 2020

Abstract

BACKGROUND: Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories. METHODS: We used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the basis of hospital and claims da..

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Grants

Awarded by Portuguese national funds (FCT/MCTES)


Awarded by Portuguese national funds through Fundaco para a Ciencia e Tecnologia (FCT), IP, under the Norma Transitaria


Awarded by Wellcome Trust/DBT India Alliance Fellowship


Awarded by Xiamen University Malaysia Research Fund


Awarded by Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig (Germany; German Federal Ministry of Education and Research)


Funding Acknowledgements

This study is funded by the Bill & Melinda Gates Foundation. AB is supported by the Public Health Agency of Canada. LAC acknowledges the Argentine Society of Medicine for supporting our research. FC acknowledges support through Portuguese national funds (UID/MULTI/04378/2019 and UID/QUI/50006/2019 with FCT/MCTES). VMC acknowledges her grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundaco para a Ciencia e Tecnologia (FCT), IP, under the Norma Transitaria DL57/2016/CP1334/CT0006. SLJ works on an influenza/RSV grant funded by Sanofi Pasteur. PJ is supported by Wellcome Trust/DBT India Alliance Fellowship [grant number IA/CPHI/14/1/501497]. YJK acknowledges support from Xiamen University Malaysia Research Fund (Grant No. XMUMRF/2018-2/ITCM/0001). SL acknowledges institutional support from the Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig (Germany; German Federal Ministry of Education and Research; grant agreement number 01EA1808A). WM is currently Program Analyst Population and Development at the United Nations Population Fund-UNFPA Country Office in Peru, which not necessarily endorses this study. PM-Z acknowledges the support awarded in 2015 by the National Council of Science and Technology of Mexico, the Inter-American Development Bank, the Organization of American States, and the National Council for Scientific and Technological Research of Costa Rica for offering them a postgraduate scholarship to be able to participate in the Global Burden of Disease technical training celebrated in Greece. AMS was supported by a fellowship from the Egyptian Fulbright Mission Program (EFMP). Editorial note: The Lancet Group takes a neutral position with respect to territorial claims in published maps and institutional affiliations.