Journal article

The reliability of nipple aspirate and ductal lavage in women at increased risk for breast cancer - a potential tool for breast cancer risk assessment and biomarker evaluation

K Visvanathan, D Santor, SZ Ali, A Brewster, A Arnold, DK Armstrong, NE Davidson, KJ Helzlsouer

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2007

Abstract

PURPOSE: Ductal lavage, a technique used to sample epithelial cells from breast ducts, has potential use in risk assessment and biomarker evaluation among women at increased risk for breast cancer. However, little is known about the reliability of the procedure. METHODS: We evaluated the reliability of nipple aspirate (NAF) and ductal lavage at two time points 6 months apart in women at increased risk for breast cancer. Eligible women had a 5-year Gail risk >or=1.66% or lifetime risk of >20%, and/or a family history or personal history of breast cancer. All ducts that produced NAF were cannulated. The kappa statistic was used to evaluate reliability of NAF production, cellular yield, and cyt..

View full abstract