Performance of the ResistancePlus MG diagnostic test for Mycoplasma genitalium using samples collected with Hologic Aptima Specimen Collection kits
Gerald L Murray, Jennifer Danielewski, Catriona S Bradshaw, Deborah A Williamson, Joshua Birnie, Jenny P Su, Vesna De Petra, Lit Y Tan, Rachel Wee, Dorothy A Machalek, Tim RH Read, Suzanne M Garland
Journal of Medical Microbiology | MICROBIOLOGY SOC | Published : 2020
Introduction. Mycoplasma genitalium is a sexually transmitted organism with high levels of resistance to the recommended first-line therapy, azithromycin. The ResistancePlus MG test concurrently detects M. genitalium, and the presence of macrolide-resistance mutations (MRM). European, UK and Australian guidelines recommend a diagnostic test that reports MRM to optimize treatment through resistance-guided therapy. Hence, for samples collected for use on other platforms, reflex testing using the ResistancePlus MG test would be beneficial.Aim. To validate the ResistancePlus MG assay using samples collected in Aptima buffer for testing on the Hologic Panther.Methodology. Positive (n=99) and ..View full abstract
Awarded by Department of Industry, Innovation and Science, The Australian Federal Government (Innovations Connections grant)
Awarded by National Health and Medical Research Council of Australia
This work was supported by the Department of Industry, Innovation and Science, The Australian Federal Government (Innovations Connections grant number ICG000220, jointly held with SpeeDx); the Department of Health, the State Government of Victoria (Victorian Medical Research Acceleration Fund, jointly held with SpeeDx), and The National Health and Medical Research Council of Australia early career fellowships for TRHR (1091536) and DAW (GNT1123854).