Sex Differences in the Risk of Barrett's Esophagus Associated With the Metabolic Effects of Obesity
Bradley J Kendall, Graeme A Macdonald, Johannes B Prins, Suzanne O'Brien, Aaron P Thrift, David C Whiteman
Journal of Clinical Gastroenterology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
GOAL: The goal of this study was to determine if there is an association between the insulin-insulin-like growth factor axis, the metabolic syndrome (MetS), type 2 diabetes mellitus and risk of Barrett's esophagus (BE), and if these associations are modified by sex. BACKGROUND: BE is more common in males. Gastroesophageal reflux disease, the major risk factor for BE occurs at similar frequencies in both sexes, suggesting that sex-related factors such as the metabolic effects of abdominal obesity may be important in the causation of BE. MATERIALS AND METHODS: A structured interview, anthropometric measures, and fasting blood were collected within a population-based case-control study. We recr..View full abstract
Awarded by National Cancer Institute
Supported by grants by the Queensland Cancer Fund, Queensland Government Smart State Fund, and the Princess Alexandra Hospital Research Foundation. The SDH was funded by the National Cancer Institute (grant RO1 CA 001833). D.C.W. and A.P.T. are supported by Fellowships from the National Health and Medical Research Council of Australia. The funding bodies played no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript.