Journal article

Targeting the centromedian thalamic nucleus for deep brain stimulation

Aaron EL Warren, Linda J Dalic, Wesley Thevathasan, Annie Roten, Kristian J Bulluss, John Archer

Journal of Neurology, Neurosurgery & Psychiatry | BMJ PUBLISHING GROUP | Published : 2020

Abstract

OBJECTIVES: Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) is an emerging treatment for multiple brain diseases, including the drug-resistant epilepsy Lennox-Gastaut syndrome (LGS). We aimed to improve neurosurgical targeting of the CM by: (1) developing a structural MRI approach for CM visualisation, (2) identifying the CM's neurophysiological characteristics using microelectrode recordings (MERs) and (3) mapping connectivity from CM-DBS sites using functional MRI (fMRI). METHODS: 19 patients with LGS (mean age=28 years) underwent presurgical 3T MRI using magnetisation-prepared 2 rapid acquisition gradient-echoes (MP2RAGE) and fMRI sequences; 16 patients proceeded to..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This study was supported by a project grant from the National Health and Medical Research Council of Australia (grant number 1108881) and a seed grant (grant number 2634) from the Rare Disease Foundation (www.rarediseasefound ation.org) and the British Columbia Children's Hospital Foundation (www.bcchf.ca).AELW was supported by a Postdoctoral Fellowship from the LGS Foundation (www.lgsfoundation.org).