Journal article

Oral Ondansetron to Reduce Vomiting in Children Receiving Intranasal Fentanyl and Inhaled Nitrous Oxide for Procedural Sedation and Analgesia: A Randomized Controlled Trial

Emmanuelle Fauteux-Lamarre, Michelle McCarthy, Nuala Quinn, Andrew Davidson, Donna Legge, Katherine J Lee, Greta M Palmer, Franz E Babl, Sandy M Hopper

Annals of Emergency Medicine | MOSBY-ELSEVIER | Published : 2020

Abstract

STUDY OBJECTIVE: Intranasal fentanyl and inhaled nitrous oxide are increasingly combined to provide procedural sedation and analgesia in the pediatric emergency setting. This regimen is attractive because of its nonparenteral administration, but is associated with a higher incidence of vomiting than nitrous oxide alone. We seek to assess whether prophylactic oral ondansetron use could reduce the incidence of vomiting associated with intranasal fentanyl and nitrous oxide for procedural sedation compared with placebo. METHODS: This was a double-blind, randomized controlled trial of oral ondansetron versus placebo conducted at a single tertiary care pediatric emergency department. Children aged..

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Funding Acknowledgements

By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org).The authors have stated that no such relationships exist. This study was funded by a grant from Murdoch Children's Research Institute. Dr. Babl was in part funded by a grant from the Royal Children's Hospital Foundation, Melbourne, Australia and a National Health and Medical Research Council Practitioner Fellowship, Canberra, Australia.