Journal article

Expanded complement of Niemann-Pick type C2-like protein genes in Clonorchis sinensis suggests functions beyond sterol binding and transport

Marziyeh Anari, Andreas J Stroehlein, Ross S Hall, Bill CH Chang, Robin B Gasser, Neil D Young

Parasites & Vectors | BMC | Published : 2020

Abstract

BACKGROUND: The parasitic flatworm Clonorchis sinensis inhabits the biliary tree of humans and other piscivorous mammals. This parasite can survive and thrive in the bile duct, despite exposure to bile constituents and host immune attack. Although the precise biological mechanisms underlying this adaptation are unknown, previous work indicated that Niemann-pick type C2 (NPC2)-like sterol-binding proteins might be integral in the host-parasite interplay. Expansions of this family in some invertebrates, such as arthropods, have shown functional diversification, including novel forms of chemoreception. Thus, here we curated the NPC2-like protein gene complement in C. sinensis, and predicted the..

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Grants

Funding Acknowledgements

This research was funded by grants from the National Health and Medical Research Council (NHMRC) and the Australian Research Council (ARC) to RBG and NDY. Other support from Yourgene Bioscience is gratefully acknowledged (RBG). NDY is supported by a NHMRC Career Development Fellowship.