Journal article

The role of microtubules in secretory protein transport

Lou Fourriere, Ana Joaquina Jimenez, Franck Perez, Gaelle Boncompain

Journal of Cell Science | COMPANY BIOLOGISTS LTD | Published : 2020

Abstract

Microtubules are part of the dynamic cytoskeleton network and composed of tubulin dimers. They are the main tracks used in cells to organize organelle positioning and trafficking of cargos. In this Review, we compile recent findings on the involvement of microtubules in anterograde protein transport. First, we highlight the importance of microtubules in organelle positioning. Second, we discuss the involvement of microtubules within different trafficking steps, in particular between the endoplasmic reticulum and the Golgi complex, traffic through the Golgi complex itself and in post-Golgi processes. A large number of studies have assessed the involvement of microtubules in transport of cargo..

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Grants

Awarded by Labex CelTisPhyBio


Awarded by Agence Nationale de la Recherche Scientifique


Awarded by La Fondation pour la Recherche Medicale


Funding Acknowledgements

Laboratory work is supported by the Institut Curie, the Centre National de la Recherche Scientifique, the Labex CelTisPhyBio (ANR-10-LABX-62-IBEID and ANR-10-IDEX-0001-02 PSL), the Agence Nationale de la Recherche Scientifique (ANR-17-CE13-0021-02, ANR-17-CE15-0025-02) and by La Fondation pour la Recherche Medicale (EQU201903007925).