Journal article

Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells

Insoo Hyun, Megan Munsie, Martin F Pera, Nicolas C Rivron, Janet Rossant

Stem Cell Reports | CELL PRESS | Published : 2020

Abstract

Over the past few years, a number of research groups have reported striking progress on the generation of in vitro models from mouse and human stem cells that replicate aspects of early embryonic development. Not only do these models reproduce some key cell fate decisions but, especially in the mouse system, they also mimic the spatiotemporal arrangements of embryonic and extraembryonic tissues that are required for developmental patterning and implantation in the uterus. If such models could be developed for the early human embryo, they would have great potential benefits for understanding early human development, for biomedical science, and for reducing the use of animals and human embryos..

View full abstract

Grants

Funding Acknowledgements

I.H. is funded by the Greenwall Foundation's "Making a Difference" grant.