Journal article
Early markers of cystic fibrosis structural lung disease: Follow-up of the ACFBAL cohort
NE Wijker, S Vidmar, K Grimwood, PD Sly, CA Byrnes, JB Carlin, PJ Cooper, CF Robertson, RJ Massie, MPC Kemner van de Corput, J Cheney, HAWM Tiddens, CE Wainwright, N George, R Carzino, M Moodie, DS Armstrong, A Martin, B Whitehead, G Rogers Show all
European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2020
Abstract
Little is known about early predictors of later cystic fibrosis (CF) structural lung disease. This study examined early predictors of progressive structural lung abnormalities in children who completed the Australasian CF Bronchoalveolar Lavage (ACFBAL) clinical trial at age 5-years and participated in an observational follow-up study (CF-FAB). Eight Australian and New Zealand CF centres participated in CF-FAB and provided follow-up chest computed-tomography (CT) scans for children who had completed the ACFBAL study with baseline scans at age 5-years. CT scans were annotated using PRAGMA-CF scoring. Ordinal regression analysis and linear regression were used to investigate associations betwe..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by grants from the Australian National Health and Medical Research Council (9937868, 351541and 1044829). C.E. Wainwright was supported through Practitioner Fellowship through The Children's Hospital Foundation Brisbane (RG0692016).