Journal article
Development and validation of a ceramide- And phospholipid-based cardiovascular risk estimation score for coronary artery disease patients
M Hilvo, PJ Meikle, ER Pedersen, GS Tell, I Dhar, H Brenner, B Schöttker, M Lääperi, D Kauhanen, KM Koistinen, A Jylhä, K Huynh, NA Mellett, AM Tonkin, DR Sullivan, J Simes, P Nestel, W Koenig, D Rothenbacher, O Nygård Show all
European Heart Journal | OXFORD UNIV PRESS | Published : 2020
Abstract
Aims Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease (CVD) events, especially cardiovascular death. As phospholipids have also been linked with CVD risk, we investigated whether the combination of ceramides with phosphatidylcholines (PCs) would be synergistic in the prediction of CVD events in patients with atherosclerotic coronary heart disease in three independent cohort studies. Methods Ceramides and PCs were analysed using liquid chromatography-mass spectrometry (LC-MS) in three studies: and results WECAC (The Western Norway Coronary Angiography Cohort) (N = 3789), LIPID (Long-Term Intervention with Pravastatin in Ischaemic Disease) trial (N = 5991..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Funding for the KAROLA study was received from the German Federal Ministry of Education and Research (01GD9820/0 and 01ER0814), the Willy Robert Pitzer Foundation, Bad Nauheim, Germany, and by the Waldburg-Zeil Clinics Isny, Germany. P.J.M. received grants from National Health and Medical Research Council during the conduct of the study.