Journal article

Development and variation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients

Mika Hilvo, Peter J Meikle, Eva Ringdal Pedersen, Grethe S Tell, Indu Dhar, Hermann Brenner, Ben Schoettker, Mitja Laaperi, Dimple Kauhanen, Kaisa M Koistinen, Antti Jylha, Kevin Huynh, Natalie A Mellett, Andrew M Tonkin, David R Sullivan, John Simes, Paul Nestel, Wolfgang Koenig, Dietrich Rothenbacher, Ottar Nygard Show all

European Heart Journal | OXFORD UNIV PRESS | Published : 2020

Abstract

AIMS: Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease (CVD) events, especially cardiovascular death. As phospholipids have also been linked with CVD risk, we investigated whether the combination of ceramides with phosphatidylcholines (PCs) would be synergistic in the prediction of CVD events in patients with atherosclerotic coronary heart disease in three independent cohort studies. METHODS AND RESULTS: Ceramides and PCs were analysed using liquid chromatography-mass spectrometry (LC-MS) in three studies: WECAC (The Western Norway Coronary Angiography Cohort) (N = 3789), LIPID (Long-Term Intervention with Pravastatin in Ischaemic Disease) trial (N = 59..

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Grants

Awarded by German Federal Ministry of Education and Research


Funding Acknowledgements

Funding for the KAROLA study was received from the German Federal Ministry of Education and Research (01GD9820/0 and 01ER0814), the Willy Robert Pitzer Foundation, Bad Nauheim, Germany, and by the Waldburg-Zeil Clinics Isny, Germany. P.J.M. received grants from National Health and Medical Research Council during the conduct of the study.