Journal article

Identification of a Sacral, Visceral Sensory Transcriptome in Embryonic and Adult Mice

CJA Smith-Anttila, EA Mason, CA Wells, BJ Aronow, PB Osborne, JR Keast

eNeuro | SOC NEUROSCIENCE | Published : 2020


Visceral sensory neurons encode distinct sensations from healthy organs and initiate pain states that are resistant to common analgesics. Transcriptome analysis is transforming our understanding of sensory neuron subtypes but has generally focused on somatic sensory neurons or the total population of neurons in which visceral neurons form the minority. Our aim was to define transcripts specifically expressed by sacral visceral sensory neurons, as a step towards understanding the unique biology of these neurons and potentially leading to identification of new analgesic targets for pelvic visceral pain. Our strategy was to identify genes differentially expressed between sacral dorsal root gang..

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Awarded by National Institutes of Health

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by National Institutes of Health Grants 1U01DK101029 (to J.R.K. and B.J.A.) and 5UO1DK094479 (to J.R.K.). Stemformatics is funded by the Australian Research Council Grant SR110001002 to Stem Cells Australia. C.A.W. is the recipient of the Australian Research Council Future Fellowship FT150100330.