Journal article

Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1

Denise Hoch, Martina Bachbauer, Caroline Poechlauer, Francisco Algaba-Chueca, Veronika Tandl, Boris Novakovic, Ana Megia, Martin Gauster, Richard Saffery, Andreas Glasner, Gernot Desoye, Alejandro Majali-Martinez

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2020

Abstract

In the first trimester of pregnancy, placental development involves a wide range of cellular processes. These include trophoblast proliferation, fusion, and differentiation, which are dependent on tight cell cycle control. The intrauterine environment affects placental development, which also includes the trophoblast cell cycle. In this work, we focus on maternal obesity to assess whether an altered intrauterine milieu modulates expression and protein levels of placental cell cycle regulators in early human pregnancy. For this purpose, we use first trimester placental tissue from lean and obese women (gestational week 5+0-11+6, n = 58). Using a PCR panel, a cell cycle protein array, and STRI..

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Grants

Awarded by doctorate program MOLIN (FWF)


Awarded by Albert Renold Travel Fellowship (EFSD)


Awarded by Austrian Science Fund (FWF)


Awarded by funds of the Oesterreichische Nationalbank (Anniversary Fund)


Funding Acknowledgements

D. Hoch was funded by the doctorate program MOLIN (FWF, W1241) and was supported by an Albert Renold Travel Fellowship (EFSD, 94420). B. Novakovic was funded by an NHMRC Australia CJ Martin Fellowship. M. Gauster was supported by the Austrian Science Fund (FWF) (P 29639, I 3304, and Doc 31-B26) and by funds of the Oesterreichische Nationalbank (Anniversary Fund, project number 18175). A. Majali-Martinez and G. Desoye were supported by funds of the Oesterreichische Nationalbank (Anniversary Fund, project number 17950).